Synthesis, physicochemical and antibacterial properties of some mixed ligand metal(II) complexes of Niacin and m-Toluic acid (In Press)

Journal of Research & Developments in Chemistry

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Aderoju A. Osowole, Austin E. Ozukwe and Temitayo O. Oluwadara

Volume 2014(2014), Article ID 840677, Journal of Research & Developments in Chemistry, 14 pages, DOI:

Received date : 25 April 2014; Accepted date : 7 July 2014; Published date : 1 August 2014

Academic editor: Majid Rezaeivala

Abstract

Metal(II) complexes of mixed ligands, Niacin (HL) and m-Toluic(HL1 ), have been synthesized and characterized by percentage metal, infrared and electronic spectroscopies, room temperature magnetic moments, melting points and conductance measurements. The metal analysis shows that the complexes analyze mostly as [M(HL)(HL1 )X].nH2O, where M = Mn, Co, Ni, Cu, Fe, Zn and X= Cl2, (NO3)2, SO4. Infrared spectra data confirm that coordination is via the Niacin’s hydroxy oxygen and nitrogen atoms; and Toluic acid’s carboxylate oxygen atoms. The room temperature magnetic moment and electronic spectra data indicate that the metal(II) complexes are all octahedral and magnetically dilute with the exception of the Cu(II) complex which is antiferromagnetic with a room temperature magnetic moment of 1.69 B.M. The molar conductances of the metal(II) complexes in DMSO show that the complexes are covalent. Interestingly, the in-vitro antibacterial studies on these metal(II) complexes, Niacin and m-Toluic acid against Bacillus cereus, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella oxytoca and Staphylococcus aureus show that the Co(II) and the Ni(II) complexes have broad-spectrum antibacterial activities against these bacteria, just like streptomycin, with inhibitory zone range of 21.0-49.0 mm and 21.0-37.0 mm, respectively.

Keywords: Antiferromagnetic, broad-spectrum, niacin, toluic acid