Irritable Bowel Syndrome Pathophysiology According to Traditional Iranian Medicine ( In Press)

Research in Endocrinology

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Ghazaleh Mosleh1 , Ph.D. candidate, Abdolali Mohagheghzadeh1,2, Ph.D., Azadeh Hamedi2 , Ph.D., Mousa Salehi3 , Ph.D , Seyed Mohammad Kazem Hosseini Asl4 *, M.D

1The Department of Traditional Pharmacy, Faculty of Pharmacy and Pharmaceutical Science Research Centre, Shiraz University of Medical Science. Shiraz, Iran

2The Department of Pharmacognosy, Faculty of Pharmacy, Shiraz University of Medical Science. Shiraz, Iran

3The department of Nutrition, science, Shiraz University of Medical Science. Shiraz, Iran

4The department of Internal Medicine, Nemazee Hospital, Shiraz, Iran

Volume , Article ID 688997, Research in Endocrinology, 12 pages, DOI:

Received date : 4 August 2013; Accepted date : 19 October 2013; Published date : 11 November 2013

Academic editor: ChingLiang Lu


Background: Irritable bowel syndrome (IBS) is a prevalent digestive disease with altered bowel habits. In the modern medicine (MM) its pathophysiology and treatment is poorly understood. Traditional Iranian Medicine (TIM), has introduced IBS from many years ago, although nowadays people think that IBS was described in 1849 AD for the first time. Methods: This article, has compared the pathophysiology of IBS based on Traditional Iranian Medicine and Modern medicine. It’s important to consider that the medical terminology of TIM is different from that of MM, but the human’s body and diseases have not been changed throughout the history, so TIM that had been efficient in the past, has the potential to cure patients in present. Results: According to investigations “Ghoolenj Rihi” is a disease that is equal to IBS-C and “Maghs Rihi” is the same as IBS-D. TIM classifies the causes of IBS, in three classes: 1- intestinal tissue problems, 2- intestinal content problems, 3-non intestinal problems. The therapeutic category of IBS according to TIM contains: Laxatives for IBS-C (and Anti-diarrhea remedies in IBS-D), Enema or suppositories, Carminatives, analgesics, compress, cupping, Bathing (or taking the special device). Conclusion: According to comparative study between TIM and MM, the pathology of IBS is due to: 1-intestinal tissue problems: smooth muscle/ endocrine/ exocrine cell dysfunction. 2- Intestinal content problems: bad foods/ some other substances that can enter the colon’s lumen and makes it irritable. 3-Non intestinal problem: is because of other body organs affecting intestine. The holistic vision about the disease, suggests new approaches to IBS treatment.

Keywords: IBS, pathophysiology, TIM