H63D But Not C282Y Mutation of HFE Gene Is Contributed In Acute Myocardial Infarction(In Press)

Research in Genetics

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Shahrokh Iravani1, Zahra Shaker2, Amin Ayatipour3, Hamed Naghoosi4 and Pedram Azimzadeh5

1,2,3AJA Cancer Research Center (ACRC), AJA University of Medical Sciences, Tehran, Iran

4Biotechnology Department, Iranian Research Organization for Science and Technology (IROST), Tehran, Iran

5Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Volume 2014(2014), Article ID 563101, Research in Genetics, 6 pages, DOI:

Received date : 27 June 2014; Accepted date : 22 October 2014; Published date : 17 November 2014

Academic editor: Kotze, Maritha J

Abstract

HFE mutation related hemochromatosis is one of the most common causes of iron overload in north European populations. The aim of present study was to investigate the association of HFE gene mutations in susceptibility to Acute Myocardial Infarction (AMI) among a sample of Iranian population. We analyzed two major mutations of HFE gene, H63D at exon2 and C282Y located in exon4 in 131 patients with AMI and 130 healthy controls. There were a significant difference in the distribution of Codon 63 mutation of the HFE gene among AMI cases and controls but there was no relationship between C282Y mutation and risk of AMI. Our results suggest that the H63D mutation of HFE gene is associated with susceptibility to AMI in Iranian population.

Keywords: Hemochromatosis, HFE gene, Mutation, Acute Myocardial Infarction