@article{nunes2013alcoholic,
  title = {Alcoholic Polyneuropathy: Clinical Assessment of Treatment Outcomes Following Therapy with Nucleotides and Vitamin B12},
  author = {Carlos Pereira Nunes and Ari Boulanger Scussel Jr and Henrique Goldberg and Gerson Goldwasser and Lisa Oliveira and Helio Rzetelna and Marco Antonio Mibielli and Alessandra Santos and Mauro Geller},
  year = 2013,
  url = {https://ibimapublishing.com/articles/RNIJ/2013/208067/},
  journal = {Research in Neurology: An International Journal},
  volume = 2013 (2013),
  pages = 16,
  doi = 10.5171/2013.208067,
  abstract = {The purpose of this study was to evaluate the clinical action of the combination of cytidine monophosphate (CMP), uridine triphosphate (UTP), and hydroxocobalamin in the treatment of patients presenting alcoholic polyneuropathy. Patients received a 6-day intramuscular treatment of: CMP 5.0mg; UTP 3.0mg; hydroxocobalamin 2.0mg; lidocaine 20mg, followed by a 30-day treatment period of thrice daily oral ingestion of: CMP 2.5mg; uridine triphosphate UTP 1.5mg; hydroxocobalamin 1.0mg. Efficacy assessments included a 100mm pain VAS, paresthesia testing, motor coordination evaluation, vibration perception testing, and 1-10 point overall condition questionnaire. Safety assessments included vital signs and adverse event monitoring throughout the study. A total of 120 patients were included in the study. The number of symptomatic patients at Assessment 4 was significantly lower in relation to pretreatment for pain (p=0.0009), paresthesia (p<0.0001), altered vibration perception (p=0.0004), and altered motor coordination (p=0.002). VAS score reduction at Assessment 4 was found to be statistically significant (p<0.0001), with improvement in overall condition assessment scores performed by the patients and the physician (p<0.0001 for both). Adverse events were observed among 27 patients, and were overall mild or moderate in severity, short-lasting, did not lead to study withdrawal. Based on the results observed in our study, we conclude that the combination of CMP, UTP, and vitamin B12 was safe and effective in the treatment of patients presenting alcoholic polyneuropathy. Treatment with the intramuscular injection form followed by oral treatment reduced pain in relation to pretreatment values, increased vitamin B12 levels and improved motor coordination among affected patients.},
  keywords = {Alcoholic Polyneuropathy, Uridine, Cytidine, Vitamin B12},
  note = Article ID: 208067
}