@article{faglia2013btype,
  title = {B-Type Natriuretic Peptide Predict Mortality in Diabetic Patients with Foot Ulcer},
  author = {Ezio Faglia and Giacomo Clerici and Maurizio Caminiti and Curci Vincenzo and Alberto Morabito and Vincenzo Prisco and Marco Prisco and Rosaria Greco and Michael Edmonds},
  year = 2013,
  url = {https://ibimapublishing.com/articles/DIAB/2013/388970/},
  journal = {Journal of Research in Diabetes},
  volume = 2013 (2013),
  pages = 9,
  doi = 10.5171/2013.388970,
  abstract = {The background of this article is to retrospectively investigate the role of B-type natriuretic peptide (BNP) levels as an independent prognostic marker for mortality in diabetic patients with foot ulcer. In the period 1 January-30 June 2009, 279 diabetic patients were admitted to our foot center because of foot ulcer: neuroischemic in 182 (65.2%), neuropathic in 97 (34.8%), infected in 233 (83.5%).  In all patients BNP (normal value: ≤ 100 pg/mL) was evaluated at admission. Mortality from any cause was established and the relationship between the recorded variables and risk of death was evaluated by the survival Cox regression model. Kaplan-Meier analysis was performed.  BNP was >100 pg/mL in 167 (59.9%) patients. 278 (99.6%) patients were followed to December 31, 2012 with a mean follow-up of 3.6  0.2 years. Seventy-one/278 (25.5%) patients died. Of these, 61 (85.9%) had a BNP value >100 pg/mL. Forty-five/71 (63.4%) patients died from cardiac cause. The most frequent cause of death was heart disease: 45/71 (63.4%). Of these, 24 patients had no history of CAD. Multivariate analysis showed the independent predictors of death to be BNP > 100 (hazard ratio 6.040; p <0.001; CI, 2.380-15.328), age (hazard ratio 1.043, p = 0.024, CI 1.001-1.082), and dialysis treatment (hazard ratio 3.145; p = 0.032; CI, 1.100-8.988). In diabetic patients with foot ulcer an elevated BNP level is a strong predictor of the excess mortality, independent of history of cardiac disease.},
  keywords = {Diabetic foot ulcer, b-type natriuretic peptide, all cause  mortality, history of cardiac disease, cardiac mortality.},
  note = Article ID: 388970
}