@article{jansen2015multimodal,
  title = {Multimodal MRI Reveals Secondarily Generalized Seizure Related Abnormalities at 1.5 T: Preliminary Findings},
  author = {Jacobus F.A. Jansen and Mariëlle C.G. Vlooswijk and Rianne P. Reijs and H.J. Marian Majoie and Paul A.M. Hofman and Albert P. Aldenkamp and Walter H. Backes},
  year = 2015,
  url = {https://ibimapublishing.com/articles/JMED/2015/397761/},
  journal = {JMED Research},
  volume = 2015 (2015),
  pages = 16,
  doi = 10.5171/2015.397761,
  abstract = {Patients with chronic epilepsy, who have suffered a high number of secondarily generalized tonic-clonic seizures (SGTCS) frequently show cognitive comorbidity. It is yet unclear whether a higher number of SGTCS is associated with tissue changes in the brain. We have investigated in patients with chronic epilepsy whether a high number of SGTCS accumulated over life is associated with microstructural changes in brain tissue. Sixteen patients with localization-related epilepsy with SGTCS underwent a multimodal quantitative Magnetic Resonance (MR) examination at 1.5 T, comprising T2 relaxometry, and diffusion weighted imaging to study microstructural changes in the temporal and frontal lobes. Fourteen healthy volunteers were also included to assess the effect of age. Patients with more than 20 SGTCS (n=8) showed a significantly lower IQ (-20%, p},
  keywords = {Epilepsy; Secondarily generalized tonic-clonic seizures; Quantitative MRI; Cognitive decline.},
  note = Article ID: 397761
}