@article{hashemi2013aging,
  title = {Aging and Quantitative Amounts of Immunoglobulin G and its Subclasses in Patients with Chronic Rhinosinusitis},
  author = {Seyyed Abbas Hashemi and Seyyed Abdollah Madani},
  year = 2013,
  url = {https://ibimapublishing.com/articles/IMMU/2013/401901/},
  journal = {Research in Immunology: An International Journal},
  volume = 2013 (2013),
  pages = 6,
  doi = 10.5171/2013.401901,
  abstract = {Aging imposes numerous immune system changes. Despite intensive researches, many disorders of age-associated immune dysfunctions have not been fully understood. Research Objective is to evaluate the effect of aging on immunoglobulin G (IgG) and its subclasses production in patients with chronic rhinosinusitis. The Study population included patients with chronic rhinosinusitis whom underwent immunoglobulins measurement. Immunoglobulin G, IgG1, IgG2, IgG3 and IgG4 were measured by MININEPHTM HUMAN IgG KIT (The binding site Ltd., Birmingham, UK). For statistical analysis ANOVA was performed. P value of less than 0.05 defined as statistically significant. The study population consisted of 65 patients with chronic rhinosinusitis including 30 female and 35 male subjects. There was significant change in IgG level of patients in category of 20 -30 year in comparison with youngest subjects (p=0.02). With comparison of patients with the oldest group (more than 40 years), there was significant change in IgG2 and IgG3 in group of 20 — 30 years (p=0.04, P= 0.033, respectively). In this regard, significant difference was noted in IgG4 in group of 30-40 years (p=0.005). This investigation showed the defects for IgG and its subclasses could lead to the finding of procedures for improvement of humoral immune responses in chronic inflammatory diseases in the future. Further studies are needed to confirm the outcomes.},
  keywords = {Aging, Chronic Rhinosinusitis, Immunoglobulin G, B cell.},
  note = Article ID: 401901
}