@article{wang2014picroside,
  title = {Picroside Ⅱ Could Reduce the Concentration of NO and Enhance the Activity of GSHPx in Cerebral Ischemic Injury in Rats},
  author = {Yue Wang and Rui Zhang and Liang Zhong and Guangyi Liu and Xiao-Jun Ji},
  year = 2014,
  url = {https://ibimapublishing.com/articles/RNIJ/2014/488911/},
  journal = {Research in Neurology: An International Journal},
  volume = 2014 (2014),
  pages = 8,
  doi = 10.5171/2014.488911,
  abstract = {Picroside II could reduce the oxidative damage induced by cerebral ischemia-reperfusion and improve nerve behavior function of rats. The aim of this study was to optimize the therapeutic dose and time window of picrosede II by orthogonal test in cerebral ischemic injury in rats. The forebrain ischemia models were established by bilateral common carotid artery occlusion (BCCAO) methods. The successful models were randomly grouped according to orthogonal experimental design and treated by injecting picroside II intraperitonenally at different ischemic time with different dose. The concentration nitric oxide (NO) in serum and brain tissue were determined by nitratase reductase assay. The activity of glutathione peroxidase (GSHPx) in serum and tissue were determined by chemical colormetry. The optimized composition of the therapeutic dose and time window of picroside II in cerebral ischemic injury was (1) ischemia 1.5h with 20mg/kg body weight according to the concentrations of NO in serum and brain tissue; (2) ischemia 1.5h with 10mg/kg and ischemia 2.0h with 20mg/kg body weight according to the activities of GSHPx in serum and brain tissue. From the principle of lowest therapeutic dose with longest time window, the optimized composition of the therapeutic dose and time window of picroside II in cerebral ischemic injury is ischemia 1.5-2.0h with 10-20mg/kg body weight.},
  keywords = {Picroside II, Cerebral ischemia, NO, GSHPx},
  note = Article ID: 488911
}