@article{yazdani2014final,
  title = {Final Sensitivity and Specificity of Different Test Combinations in Screening},
  author = {Shahram Yazdani and Atousa Iranpour Asli and Arash Iranpour Asli and Parvin Sarbakhshand Saman Salemi},
  year = 2014,
  url = {https://ibimapublishing.com/articles/JMED/2014/558523/},
  journal = {JMED Research},
  volume = 2014 (2014),
  pages = 10,
  doi = 10.5171/2014.558523,
  abstract = {Screening is a way of looking for patients who do not seem to have major medical problems. Screening tests usually include several phases. In double phase screening, one test is to find the potential patient, and then another test is to prove the disease in those patients. The combination of these two tests is important and can be either "in series", where running or not running the second test depends on the results of the first one, or "in parallel" where the second test is independently performed regardless of what the first test result is. In this article we compared the combined tests based on their final sensitivity and specificity using mathematical analysis to determine how the order of different tests with different sensitivity, and specificity can impact the final specificity and sensitivity of the combined tests. We could prove that in none of the combined tests the final sensitivity and specificity is affected by the sequence of the tests, but the amount of intermediate false positive is affected, so that if the first test is more sensitive, we will have more false positives after the first test.  The type of screening we choose relies on what our aim is for doing that screening, and a combination of tests should be selected, so that the selected tests are acceptable in terms of false positive but whether, to do the more sensitive test first or the more specific one, there is no difference in the final sensitivity or specificity.},
  keywords = {Screening, Specificity, Sensitivity, Combination.},
  note = Article ID: 558523
}