@article{felix2015pneumococcal,
  title = {Pneumococcal meningitis in Cuban children and adolescents: A fifteen years follow up},
  author = {Dickinson Meneses Felix and Rodríguez Ortega Misladys and Toraño Peraza Gilda},
  year = 2015,
  url = {https://ibimapublishing.com/articles/PRIJ/2015/596251/},
  journal = {Pediatrics Research International Journal},
  volume = 2015 (2015),
  pages = 11,
  doi = 10.5171/2015.596251,
  abstract = {Pneumococcal meningitis still remains a serious global threat for children and adolescents. The aim of this study was to assess main epidemiological features of Pneumococcal meningitis, some risks for fatality and major pneumococcal serogroup/serotypes and their potential coverage by the available pneumococcal conjugate vaccines. An observational study of 569 confirmed cases (1998-2012) was completed based on surveillance system. Incidence, case-fatality rate and seasonality were estimated.  Association of different variables related with dead was assessed by using Relative Risk and its 95% confidence interval with p0.05) in 6-11, 12-14 and 15-19 years old (Relative Risk=3.61, 3.00 and 3.16 respectively). Proportion of S. pneumoniae isolates covered by commercial pneumococcal conjugate vaccines ranked 53.0-71.4%. Pneumococcal meningitis affects predominantly infants and is particularly lethal in Cuba. Seasonal increase occurs in winter. Hospitalization ≥24 hours may contribute to increase fatality. Main S. pneumoniae serogroups/serotypes circulating among Cuban children and adolescents are included in commercial pneumococcal conjugated vaccines. We emphasize the importance of continuous nationwide surveillance to achieve more comprehensive insights into pneumococcal epidemiology as well as their contribution to the assessment of future immunization strategies.},
  keywords = {Pneumococcal meningitis, epidemiology, pneumococcal conjugated vaccines.},
  note = Article ID: 596251
}