@article{kodaka2016gcsfproducing,
  title = {G-CSF-producing renal cell carcinoma characterized by IL-8-induced marked neutrophil infiltration to tumor tissue},
  author = {Taiichi Kodaka and Emiko Ishikawa Sakane and Hayato Maruoka and Hiroko Tsunemine4 and Hiroshi Akasaka and Kiminari Ito and Tetsuya Miura and Tomoo Itoh and Takayuki Takahashi},
  year = 2016,
  url = {https://ibimapublishing.com/articles/ACRT/2016/711926/},
  journal = {Advances in Cancer Research & Treatment},
  volume = 2016,
  pages = 12,
  doi = 10.5171/2016.711926,
  abstract = {Although G-CSF-producing tumor is well-known, co-production of IL-8 by such tumor and IL-8-induced neutrophil chemotaxis to tumor tissue have not been recognized. A 65-year-old male was diagnosed with papillary renal cell carcinoma accompanied by marked intratumoral neutrophil infiltration after left radical nephrectomy. At presentation, laboratory tests showed a white blood cell count of 47.8×109/l with 84.1% neutrophils and a high CRP of 18.3 mg/dl. Serum concentrations of G-CSF, IL-6, and IL-8 were elevated to 143 pg/ml, 474 pg/ml, and 1,260 pg/ml, respectively. After the operation, the white cell count and serum concentrations of these cytokines returned to 3 normal levels. Real-time quantitative PCR of the tumor tissue revealed high gene expressions of G-CSF and IL-8, which appeared to be the cause of the leukocytosis and intratumoral neutrophil infiltration.},
  keywords = {G-CSF, IL-8, renal cell carcinoma, neutrophil infiltration},
  note = Article ID: 711926
}