@article{lisowskamyjak2016search,
  title = {Search for the Laboratory Parameters of Inflammation In The Serum and Faeces of Patients with Irritable Bowel Syndrome},
  author = {Barbara Lisowska-Myjak and Jacek Muszyński and Hanna Zborowska},
  year = 2016,
  url = {https://ibimapublishing.com/articles/GAST/2016/730986/},
  journal = {International Journal of Gastroenterology Research and Practice},
  volume = (2016),
  pages = 11,
  doi = 10.5171/2016.730986,
  abstract = {Background: Pathophysiological mechanisms of IrritableBowel Syndrome (IBS) are unknown and there are no specific markers unique to this disorder. The hypothesis of a subclinical gradual development of local intestinal inflammation which generates IBS remains to be confirmed. The aim of the study was to search for a laboratory parameter or their panel among the acute-phase proteins in the blood and confirm their possible association with faecal calprotectin and alpha-1-antitrypsin which are specific markers for local intestinal inflammation. 2 Methods: Concentration of serum alpha-1-antitrypsin, orosomucoid (ORS), transferrin , hsCRP and faecal alpha-1-antitrypsin were measured by immunopreciptation while faecal calprotectin by enzyme-linked immunosorbent assay in 38 patients with IBS (Rome II diagnostic criteria), including 18 patients with diarrhoea-predominant IBS , 12 with constipation-predominant IBS and 8 with alternating IBS . Results: In all patients with IBS, there was significant correlation between the serum concentrations of positive acute-phase proteins (alpha-1-antitrypsin, ORS, hsCRP) . The concentrations of faecal calprotectin (µg/g dry faeces) considerably varied between subjects (range: 0.16-19.83) and a significant correlation was observed with ORS alone (r=0.40, p=0.014). In diarrhoea-predominant IBS : (1) the ORS concentrations were elevated compared to constipation-predominant IBS (p=0.030); (2) hs-CRP was increased (p=0.007) in patients with ORS concentrations > 1.0 g/l. Conclusions: ORS is the serum acute-phase protein with the highest specificity for diarrhoea-predominant IBS . Significant correlation between faecal calprotectin and serum ORS in diarrhoea-predominant IBS suggest the usefulness of the two parameters as a diagnostic panel to screen patients with suspicion of IBS for low-grade intestinal inflammation.},
  keywords = {irritable bowel syndrome , laboratory parameters, inflammation, biomarkers in faeces and serum},
  note = Article ID: 730986
}