@article{hussain2013species,
  title = {Species Distribution and Susceptibilities of Bacteraemic Isolates from a United Kingdom Level 3 Neonatal Intensive Care Unit, a 5 Year Experience},
  author = {Abid Hussain and Imogen Storey},
  year = 2013,
  url = {https://ibimapublishing.com/articles/PRIJ/2013/766952/},
  journal = {Pediatrics Research International Journal},
  volume = 2013 (2013),
  pages = 5,
  doi = 10.5171/2013.766952,
  abstract = {Empirical antimicrobial guidelines are constantly evolving in response to laboratory susceptibility data. Broad spectrum agents exert a selection pressure gradually increasing antimicrobial resistance over time. In the level 3 neonatal intensive care unit (NICU), the majority of blood culture isolates are coagulase negative staphylococci (CoNS), which require appropriate empirical therapy.  To assess antimicrobial resistance trends of CoNS and other commonly isolated organisms over a five year period in a busy neonatal unit. A retrospective analysis of all laboratory positive neonatal blood cultures from January 2005 to October 2010 was undertaken, recording species and susceptibility data. During the 5 year period 794 positive blood cultures were identified, with 639 isolates (80.5%) identified as CoNS. The remaining 155 included 34 other Gram positives (4.3%) and 121 Gram negatives (16.5%). There is an increase in CoNS resistance over 5 years to cloxacillin with no resistance to vancomycin identified. Gram negative resistance patterns appear more stable, with a decreasing resistance to amoxicillin reflecting changes in prescribing policies. Changing local trends in antimicrobial susceptibility should be considered when formulating empiric antimicrobial policies.},
  keywords = {Neonatal, sepsis, bacteraemia, coagulase negative staphylococci.},
  note = Article ID: 766952
}