@article{bertuzzi2014stem,
  title = {Stem Cell’s Behavioral Effects in Rats in a Model of Alzheimer’s Disease},
  author = {Leticia Bertuzzi and Annelise Ribeiro da Rosa and Anna Ourique and Leonardo Wentz and Rafael Nicolaidis and Kamilla Torquato and Amanda Stapenhorst and Patrícia Santos da Silva and Élida Fluck and Pedro Chagastelles and Patricia Pranke and Alcyr Alves de Oliveira},
  year = 2014,
  url = {https://ibimapublishing.com/articles/ASC/2014/805238/},
  journal = {Advances in Stem Cells},
  volume = 2014 (2014),
  pages = 13,
  doi = 10.5171/2014.805238,
  abstract = {Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder related to aging and central nervous system dysfunctions. Besides compromising the memory, AD is responsible for deficits in attention, orientation, organization, the capacity of planning and judging, among other cognitive functions, leading to the inability of living independently. The pharmacological treatment is only palliative. Thus, researches on stem cells implants emerge as promising prospects for the cure of central nervous system’s disorders. The aim of this study was to investigate the effects of stem cells implants from human dental pulp, human adipose tissue and mice renal tissue on the behavior of rats in a model for AD. To this purpose, male adult rats of Wistar strain underwent stereotactic surgery for lesions of the nucleus basalis magnocellularis with unilateral AMPA infusions. Twenty one days from surgery for lesions, animals received the stem cells implants. Subjects were, then, evaluated in the following behavioral tests: open field, elevated-T maze and object recognition. Immune histological exams pointed out the success of the AMPA infusions. Results showed an improvement in the behavioral performance of implanted rats with stem cells over the non-implanted group in the number of crossings in the open field (p= 0.001), time spent in the periphery, center area and latency (p= 0.012). In the elevated T-maze, the significant mean was identified in the inhibitory avoidance (p= 0.028). Implants of stem cells demonstrated an improvement in the performance of implanted animals compared to the non-implanted group.},
  keywords = {Alzheimer’s disease; Stem Cells; Neural Transplantation; Behavior.},
  note = Article ID: 805238
}