@article{pavlina2014lowlevel,
  title = {Low-Level Gonosomal Mosaic (LLGM) In Female Reproduction},
  author = {Capkova Pavlina and Alena Santava and Milena Krskova and Katerina Adamova and Blazena Hladikova-Zborilova and Radka Nedomova and Ales Sobek and Vaclava Curtisova and Ishraq Dhaifalah},
  year = 2014,
  url = {https://ibimapublishing.com/articles/GYNE/2014/884168/},
  journal = {Obstetrics & Gynecology: An International Journal},
  volume = 2014(2014),
  pages = 14,
  doi = 10.5171/2014.884168,
  abstract = {Method: Cytogenetic and fluorescent in situ hybridization ( FISH )analyses on cultured and uncultured blood samples. Results: There was no significant difference in the incidence of LLGM in patients from the tested group vs. control. The mean of X aneuploidy cells proportion was 2.2 % in the tested vs 1.2 % in control group by cytogenetic examination (p> 0.05). The frequency of X aneuploidy cells in tested group vs. control was significantly higher when the examination was performed by FISH: mean = 5,4 % in cultured and 6,4 % in uncultured samples vs. 3.9 % and 3.6 % resp. in the control (p<0.005). Conclusion: FISH provides more detailed assessment of X aneuploidy cell proportion in patients treated for infertility. Incidence of LLGM and frequency of X aneuploidy cells increases with age in females generally. Accelerated increase of X aneuploidy occurrence observed in the infertile group implies that the mitotic error occurs more frequently in females with reproductive failure. IVF outcomes did not differ between tested and control cohort. Our results show that the patients with LLGM show higher predisposition to recurrent miscarriage (P<0.05).},
  keywords = {infertility, low-level gonosomal mosaic, FISH, recurrent spontaneous abortions (RSA)},
  note = Article ID: 884168
}