@article{kalbkhani2014effects,
  title = {Effects of Platelet Rich Plasma (PRP) in Treatment of Experimentally Induced Osteoarthritis in Rabbit’s Knee Joint},
  author = {Morteza Kalbkhani and Seifollah N. Dehghani and Alireza Najafpour and Naji S. Haddadi and Kalbkhani Mohamad Hossein},
  year = 2014,
  url = {https://ibimapublishing.com/articles/ASC/2014/994022/},
  journal = {Advances in Stem Cells},
  volume = 2014 (2014),
  pages = 10,
  doi = 0.5171/2014.994022,
  abstract = {Osteoarthritis is the most common type of arthritis and the major cause of chronic disability in musculoskeletal mobility in the elderly populations worldwide. In this study, the scaffold free autologous platelet rich plasma (PRP) in an experimental animal model of osteoarthritis (OA) by direct intra articular injection was used.Seventeen New Zealand white adult rabbits of both sexes were used. Osteoarthritis was induced by anterior cruciate ligament transection of knee joints. Eight weeks following operation, a single dose of (0.5 ml) Platelet Rich plasma (PRP) was delivered into the injured knee by direct intra articular injection. The control group received no treatment. The knees were examined on 12 and 16 weeks past from the initial operation. The healing status   was investigated histopathologically.Pathologic assessment confirmed development of OA changes after 8 weeks which was advanced at 12 weeks in the control group. PRP treated Rabbits showed lower degree of cartilage degeneration, less osteophyte formation, and minimal subchondral sclerosis at 12 weeks following surgery compared to the control group. The PRP group had near to normal joint structure at 16 week postoperative interval. This study showed that the PRP could potentially be used   for the treatment of osteoarthritis.},
  keywords = {Histopathologic assessment, Osteoarthritis, Platelet-Rich Plasma, Rabbits, Stifle joint.},
  note = Article ID: 994022
}