Regression of Murine Ehrlich Ascites Carcinoma Using Tumor-Targeting Salmonella VNP20009 – Comparison with the Effect of the Anticancer Drug Doxorubicin
Advances in Cancer Research & Treatment
The limited selectivity of therapeutic agents for tumor cells and their inability to act on poorly vascularized areas of tumors, remain among the primary limitations to cancer therapy. Several studies reported that Salmonella typhimurium VNP20009 (VNP) preferentially targets hypoxic/anoxic cores of solid tumors. Here the…