Inhibition of Nitric Oxide Generation in Mononuclear Splenocytes from Multiple-Low-Dose-Streptozotocin Diabetic Mice
JMED Research
Mice injected with multiple low dose of streptozotocin (mld-SZ) or transferred with mononuclear splenocytes (MS) from mld-SZ donors constitute animal models that allow the study of autoimmune diabetes. Mld-SZ mice show a progressive beta-cell destruction iniciated during non-specific islet inflammation involving free radicals as nitric…