The need to give support to patients with diabetes through the use of e-health has become increasingly necessary in recent times. This study aims to determine how e-health applications can benefit the self-management of diabetes in patients in Saudi Arabia through a systematic literature review. Barriers and solutions e-health for the self-management of diabetes are the core focus of this study. Google Scholar, JSTOR, PubMed and Research Gate were used to access articles published. Mobile-enabled and e-health applications were consistently found promising in most of the papers. The search yielded 20 usable papers, described then categorised according to the topic and direction of findings. Some barriers found in the study are; integration of patient records at the national level, training of people operating and maintaining the system, etc. The study found that cultural, religious and social practices of the societies significantly affect the effective use of e-health in the study area and everyone including parents need to be educated.