Exploring Gene-Treatment Interactions: Dissociated Effect of COMT Val108/158Met Genotype on Negative Symptoms Response to Haloperidol and Risperidone Vs Clozapine(In Press)
Research in Genetics
Aims: this study aims to evaluate the effect of COMT rs 4680 (Val108/158Met) polymorphism, known to regulate dopamine levels, on specific response pattern to antipsychotics characterized by different dopaminergic activity. 2 Materials and Methods: the sample included 153 subjects diagnosed with schizophrenia, treated either with…